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Consequences of Other Medication on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (significant route) and CYP2C9 (minimal route). As a result, inhibitors of such isoenzymes might cut down sildenafil clearance and inducers of those isoenzymes might raise sildenafil clearance.Will not share sildenafil with Others, regardless of wheth